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2015 ; 29
(4
): 460-4
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Outcomes following cataract surgery in choroideremia
#MMPMID25592124
Edwards TL
; Groppe M
; MacLaren RE
Eye (Lond)
2015[Apr]; 29
(4
): 460-4
PMID25592124
show ga
PurposeTo present a case series of cataract surgery outcomes in choroideremia
eyes with an emphasis on the safety of this common operation in advanced stages
of the disease.MethodsA single centre retrospective interventional case series
comprising six patients with varying degrees of visual loss secondary to
choroideremia underwent cataract surgery at a single tertiary eye hospital. Pre-
and post-operative best-corrected Snellen visual acuity, spectral domain optical
coherence tomography (SD-OCT), and slit lamp examination were performed together
with fundus autofluorescence (FAF) and colour fundus photographs.The prevalence
of intra- or post-operative complications, post-operative visual outcome, and
change in central macular thickness were recorded.ResultsThe pre-operative
best-corrected Snellen visual acuity in the operated eyes ranged from 6/12
(20/40) to PL. All but one patient had either an objective or a subjective
improvement in visual acuity. There was no evidence of retinal phototoxicity or
post-operative cystoid macular oedema (CMO). Three patients developed early
capsular fibrosis.ConclusionsAlthough the residual functioning retina in
choroideremia patients may be potentially vulnerable, this report finds no
evidence of iatrogenic vision loss after uncomplicated cataract surgery. This
suggests that cataract surgery may be performed safely in choroideremia patients,
although a guarded prognosis for visual improvement should be emphasized in the
informed consent.
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