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2017 ; 9
(8
): 2684-2691
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Outcomes after lung transplantation
#MMPMID28932576
Thabut G
; Mal H
J Thorac Dis
2017[Aug]; 9
(8
): 2684-2691
PMID28932576
show ga
With more than 50,000 procedures having been performed worldwide, lung
transplantation (LT) has become the standard of care for patients with end-stage
chronic respiratory failure. LT leads to dramatic improvements in both pulmonary
function and health related quality of life. Survival after LTs has steadily
improved, but still lags far behind that observed after other solid organ
transplantations, as evidenced by a median survival rate that currently stands at
5.8 years. Because of these disappointing results, the ability of LT to expand
survival has been questioned. However, the most recent studies, based on
sophisticated statistical modeling suggest that LT confers a survival benefit to
the vast majority of lung transplant recipients. Chronic lung allograft
dysfunction (CLAD) that develops in about 50% of recipients 5 years after LT is a
major impediment to lung transplant survival. A better understanding of the
mechanisms underlying CLAD could allow for better post-transplant survival.