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2017 ; 8
(35
): 58480-58493
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Osthole inhibits bone metastasis of breast cancer
#MMPMID28938572
Wu C
; Sun Z
; Guo B
; Ye Y
; Han X
; Qin Y
; Liu S
Oncotarget
2017[Aug]; 8
(35
): 58480-58493
PMID28938572
show ga
Bone is one of the most common sites for breast cancer metastasis, which greatly
contributes to patient morbidity and mortality. Osthole, a major extract from
Cnidium monnieri (L.), exhibits many biological and pharmacological activities,
however, its potential as a therapeutic agent in the treatment of breast cancer
bone metastases remain poorly understood. In this study, we set out to
investigate whether osthole could inhibit breast cancer metastasis to bone in
mice and clarified the potential mechanism of this inhibition. In the murine
model of breast cancer osseous metastasis, mice that received osthole developed
significantly less bone metastases and displayed decreased tumor burden when
compared with mice in the control group. Osthole inhibited breast cancer cell
growth, migration, and invasion, and induced apoptosis of breast cancer cells.
Additionally, it also regulated OPG/RANKL signals in the interactions between
bone cells (osteoblasts and osteoclasts) and cancer cells. Besides, it also
inhibited TGF-?/Smads signaling in breast cancer metastasis to bone in MDA-231BO
cells. The results of this study suggest that osthole has real potential as a
therapeutic candidate in the treatment of breast cancer patients with bone
metastases.
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