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2014 ; 48
(3
): 247-54
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Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors
#MMPMID24932029
Wadhwa N
Indian J Orthop
2014[May]; 48
(3
): 247-54
PMID24932029
show ga
Osteosarcoma (OS), the commonest malignancy of osteoarticular origin, is a very
aggressive neoplasm. Divergent histologic differentiation is common in OS; hence
triple diagnostic approach is essential in all cases. 20% cases are atypical
owing to lack of concurrence among clinicoradiologic and pathologic features
necessitating resampling. Recognition of specific anatomic and histologic
variants is essential in view of better outcome. Traditional prognostic factors
of OS do stratify patients for short term outcome, but often fail to predict
their long term outcome. Considering the negligible improvement in the patient
outcome during the last 20 years, search for novel prognostic factors is in
progress like ezrin vascular endothelial growth factor, chemokine receptors,
dysregulation of various micro ribonucleic acid are potentially promising. Their
utility needs to be validated by long term followup studies before they are
incorporated in routine clinical practice.