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2015 ; 2015
(ä): 564934
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Osteoprotegerin in Cardiometabolic Disorders
#MMPMID26078757
Pérez de Ciriza C
; Lawrie A
; Varo N
Int J Endocrinol
2015[]; 2015
(ä): 564934
PMID26078757
show ga
Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone
remodelling, has been recently related to cardiovascular disease (CVD). Human
studies show a positive relationship between circulating OPG, vascular damage,
and CVD, and as such OPG has emerged as a potential biomarker for CVD. This
review focuses on the relationship between circulating OPG and different
endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The
association of OPG with diabetic complications (neuropathy, nephropathy, or
retinopathy) as well as with atherosclerosis, coronary artery calcification,
morbidity, and mortality is pointed out. Moreover, OPG modulation by different
treatments is also established. Besides, other associated diseases such as
obesity, hypertension, and metabolic syndrome, which are known cardiovascular
risk factors, are also considered.