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2017 ; 14
(1
): 45-52
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Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies
#MMPMID27822001
Birt MC
; Anderson DW
; Bruce Toby E
; Wang J
J Orthop
2017[Mar]; 14
(1
): 45-52
PMID27822001
show ga
This review article summarizes the recent advances in pathogenic mechanisms and
novel therapeutic strategies for osteomyelitis, covering both periprosthetic
joint infections and fracture-associated bone infections. A better understanding
of the pathophysiology including the mechanisms for biofilm formation has led to
new therapeutic strategies for this devastating disease. Research on novel local
delivery materials with appropriate mechanical properties, lower exothermicity,
controlled release of antibiotics, and absorbable scaffolding for bone
regeneration is progressing rapidly. Emerging strategies for prevention, early
diagnosis of low-grade infections, and innovative treatments of osteomyelitis
such as biofilm disruptors and immunotherapy are highlighted in this review.