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10.1128/microbiolspec.MCHD-0011-2015 http://scihub22266oqcxt.onion/10.1128/microbiolspec.MCHD-0011-2015 C4920143!4920143 !27337470     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27337470 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27337470 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microbiol+Spectr 2016 ; 4 (3 ): ä Nephropedia Template TP {{tp|p=27337470 |t=2016. Osteoclasts-Key Players in Skeletal Health and Disease |pdf=|usr=}}{{27337470 }} gab.com Text Osteoclasts-Key Players in Skeletal Health and Disease JO: Microbiol Spectr http://www.kidney.de/pget.php?&tw=1&pmid=27337470 #FOAvip The differentiation of osteoclasts (OCs) from early myeloid progenitors is a tightly regulated process that is modulated by a variety of mediators present in the bone microenvironment. Once generated, the function of mature OCs depends on cytoskeletal features controlled by an ?v?3-containing complex at the bone-apposed membrane and the secretion of protons and acid-protease cathepsin K. OCs also have important interactions with other cells in the bone microenvironment, including osteoblasts and immune cells. Dysregulation of OC differentiation and/or function can cause bone pathology. In fact, many components of OC differentiation and activation have been targeted therapeutically with great success. However, questions remain about the identity and plasticity of OC precursors and the interplay between essential networks that control OC fate. In this review, we summarize the key principles of OC biology and highlight recently uncovered mechanisms regulating OC development and function in homeostatic and disease states. Twit Text FOAVip Osteoclasts-Key Players in Skeletal Health and Disease ????Microbiol Spectr http://www.kidney.de/pget.php?&tw=1&pmid=27337470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27337470 #FOAvip English Wikipedia <ref>{{Cite pmid|27337470 }}</ref> Osteoclasts-Key Players in Skeletal Health and Disease #MMPMID27337470 Novack DV ; Mbalaviele G Microbiol Spectr 2016[Jun]; 4 (3 ): ä PMID27337470 show ga The differentiation of osteoclasts (OCs) from early myeloid progenitors is a tightly regulated process that is modulated by a variety of mediators present in the bone microenvironment. Once generated, the function of mature OCs depends on cytoskeletal features controlled by an ?v?3-containing complex at the bone-apposed membrane and the secretion of protons and acid-protease cathepsin K. OCs also have important interactions with other cells in the bone microenvironment, including osteoblasts and immune cells. Dysregulation of OC differentiation and/or function can cause bone pathology. In fact, many components of OC differentiation and activation have been targeted therapeutically with great success. However, questions remain about the identity and plasticity of OC precursors and the interplay between essential networks that control OC fate. In this review, we summarize the key principles of OC biology and highlight recently uncovered mechanisms regulating OC development and function in homeostatic and disease states. |*Cell Differentiation [MESH] |Animals [MESH] |Bone Diseases/pathology [MESH] |Bone and Bones/physiology [MESH] |Humans [MESH]Osteoclasts-Key Players in Skeletal Health and Disease (epmc).pdf DeepDyve Pubget Overpricing