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2014 ; 8
(4
): 482-90
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Osteochemonecrosis: an overview
#MMPMID25409847
Hellstein J
Head Neck Pathol
2014[Dec]; 8
(4
): 482-90
PMID25409847
show ga
Osteonecrosis of the jaw to a certain extent has been with us for many years. But
recently the advent of various medications such as bisphosphonates, VEGF
inhibitors, tyrosine kinase inhibitors and humanized antibodies to osteoclastic
action have resulted in thousands of cases. While the bisphosphonates continue to
be the most common medication associated with osteochemonecrosis antibodies such
as denosumab which irreversibly act on osteoclastic action are also being
reported. This narrative review will serve as an update with a focus on some of
the histopathologic features discussed and reviewed. Perhaps even more uncommonly
seen in past reports a discussion of features possibly observed while grossing
specimens will be discussed. At the end of this report is hoped that the
pathologist will have a better understanding of the historical features, clinical
settings, gross examination features as well as histopathologic features
associated with osteochemonecrosis.
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