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10.2147/DNND.S84742 http://scihub22266oqcxt.onion/10.2147/DNND.S84742 C6053087!6053087 !30050365     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30050365 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Degener+Neurol+Neuromuscul+Dis 2016 ; 6 (ä): 17-24 Nephropedia Template TP {{tp|p=30050365 |t=2016. Orthostatic tremor: current challenges and future prospects |pdf=|usr=}}{{30050365 }} gab.com Text Orthostatic tremor: current challenges and future prospects JO: Degener Neurol Neuromuscul Dis http://www.kidney.de/pget.php?&tw=1&pmid=30050365 #FOAvip This review provides an outlook of orthostatic tremor (OT), a rare adult-onset tremor characterized by subjective unsteadiness during standing that is relieved by sitting or walking. Recent case series with a long-time follow-up have shown that the disease is slowly progressive, spatially spreads to the upper limbs, and other neurological disorders may develop in about one-third of the patients. The diagnosis of OT hinges on the typical history of unsteadiness during standing, which is confirmed by electromyographic findings of a 13-18 Hz tremor that is typically absent during tonic activation while the patient is sitting and lying. Although the tremor is generated by a central oscillator, cerebellar and/or basal ganglia dysfunction are needed for its manifestation (double lesion hypothesis). However, functional neuroimaging findings have not consistently implicated the dopaminergic system in its pathogenesis. Drug treatments have been largely disappointing with no sustained benefits, although thalamic deep brain stimulation has helped some patients. Large-scale follow-up studies, more drug trials, and novel therapies are urgently needed. Twit Text FOAVip Orthostatic tremor: current challenges and future prospects ????Degener Neurol Neuromuscul Dis http://www.kidney.de/pget.php?&tw=1&pmid=30050365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050365 #FOAvip English Wikipedia <ref>{{Cite pmid|30050365 }}</ref> Orthostatic tremor: current challenges and future prospects #MMPMID30050365 Adebayo PB Degener Neurol Neuromuscul Dis 2016[]; 6 (ä): 17-24 PMID30050365 show ga This review provides an outlook of orthostatic tremor (OT), a rare adult-onset tremor characterized by subjective unsteadiness during standing that is relieved by sitting or walking. Recent case series with a long-time follow-up have shown that the disease is slowly progressive, spatially spreads to the upper limbs, and other neurological disorders may develop in about one-third of the patients. The diagnosis of OT hinges on the typical history of unsteadiness during standing, which is confirmed by electromyographic findings of a 13-18 Hz tremor that is typically absent during tonic activation while the patient is sitting and lying. Although the tremor is generated by a central oscillator, cerebellar and/or basal ganglia dysfunction are needed for its manifestation (double lesion hypothesis). However, functional neuroimaging findings have not consistently implicated the dopaminergic system in its pathogenesis. Drug treatments have been largely disappointing with no sustained benefits, although thalamic deep brain stimulation has helped some patients. Large-scale follow-up studies, more drug trials, and novel therapies are urgently needed. äOrthostatic tremor: current challenges and future prospects (epmc).pdf DeepDyve Pubget Overpricing