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2016 ; 7
(ä): 1655
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Origin of the Autophagosomal Membrane in Plants
#MMPMID27867391
Zhuang X
; Chung KP
; Jiang L
Front Plant Sci
2016[]; 7
(ä): 1655
PMID27867391
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During autophagy, cargo molecules destined for degradation are sequestrated into
a double-membrane structure called autophagosome, which subsequently fuses with
the vacuole. An isolation membrane structure (also called the phagophore)
initiates from the platform termed PAS (phagophore assembly site or
preautophagosomal structure), which then elongates and expands to become the
completed autophagosome. The origin of the membrane for autophagosome formation
has been extensively investigated but remains an enigma in the field of
autophagy. In yeast and mammalian cells multiple membrane sources have been
suggested to contribute to autophagosome formation at different steps, from
initiation through expansion and maturation. Recent studies in plants have
provided a significant advance in our understanding of the conserved role of
autophagy and the underlying mechanism for autophagosome formation. Here, we will
discuss and evaluate these new findings on autophagosome formation in plants,
with a particular focus on the origin of plant autophagosomal membranes.