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2015 ; 2015
(ä): ä Nephropedia Template TP
BMJ Clin Evid
2015[Nov]; 2015
(ä): ä PMID26618560
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INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus insecticides
can cause acute parasympathetic system dysfunction, muscle weakness, seizures,
coma, and respiratory failure. Prognosis depends on the dose and relative
toxicity of the specific compound, as well as pharmacokinetic factors. METHODS
AND OUTCOMES: We conducted a systematic overview, aiming to answer the following
clinical question: What are the effects of oxime treatment for acute
organophosphorus insecticide poisoning? We searched: Medline, Embase, The
Cochrane Library, and other important databases up to October 2014 (Clinical
Evidence overviews are updated periodically; please check our website for the
most up-to-date version of this overview). RESULTS: At this update, searching of
electronic databases retrieved 25 studies. After deduplication and removal of
conference abstracts, 14 records were screened for inclusion in the overview.
Appraisal of titles and abstracts led to the exclusion of eight studies and the
further review of six full publications. Of the six full articles evaluated, one
update of a systematic review previously included in this review was added. We
performed a GRADE evaluation for six PICO combinations. CONCLUSIONS: In this
systematic overview, we categorised the efficacy for two comparisons based on
information about the effectiveness and safety of oximes versus placebo or no
oximes and oximes versus each other.
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