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2020 ; 2020
(ä): 5847876
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Organoids as a Powerful Model for Respiratory Diseases
#MMPMID32256609
Li Y
; Wu Q
; Sun X
; Shen J
; Chen H
Stem Cells Int
2020[]; 2020
(ä): 5847876
PMID32256609
show ga
Insults to the alveoli usually lead to inefficient gas exchange or even
respiratory failure, which is difficult to model in animal studies. Over the past
decade, stem cell-derived self-organizing three-dimensional organoids have
emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar
organoids have improved our understanding of the mechanisms underlying tissue
homeostasis and pathological alterations in alveoli. From this perspective, we
review the state-of-the-art technology on establishing alveolar organoids from
endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as
well as the use of alveolar organoids for the study of respiratory diseases,
including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory
virus infection. We also discuss challenges that need to be overcome for future
application of alveolar organoids in individualized medicine.