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10.1016/j.gde.2015.02.007 http://scihub22266oqcxt.onion/10.1016/j.gde.2015.02.007 C4476933!4476933 !25796043     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25796043 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Curr+Opin+Genet+Dev 2015 ; 30 (?): 42-8 Nephropedia Template TP {{tp|p=25796043 |t=2015. Organoid development in cancer genome discovery |pdf=|usr=}}{{25796043 }} gab.com Text Organoid development in cancer genome discovery JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=25796043 #FOAvip The tumor response to most therapeutic agents in cancer is highly unpredictable. Cancer models which can adequately represent tumor heterogeneity and predict in vivo drug sensitivity are intense areas of investigation. Cancer cell lines and patient-derived xenograft models are the most frequently used models in cancer research and anticancer drug screening. Recently, cancer 'organoid' culture conditions have been developed to establish in vitro growth of patient-derived samples at higher efficiency and they are very promising for large scale drug screening and fundamental cancer biology research. Here, we leverage our experience in prostate cancer to discuss the advantages and limitations of these cancer models and summarize the development of cancer organoid culture--a development which may provide a new path towards personalized medicine in the future. Twit Text FOAVip Organoid development in cancer genome discovery ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=25796043 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25796043 #FOAvip English Wikipedia <ref>{{Cite pmid|25796043 }}</ref> Organoid development in cancer genome discovery #MMPMID25796043 Gao D ; Chen Y Curr Opin Genet Dev 2015[Feb]; 30 (?): 42-8 PMID25796043 show ga The tumor response to most therapeutic agents in cancer is highly unpredictable. Cancer models which can adequately represent tumor heterogeneity and predict in vivo drug sensitivity are intense areas of investigation. Cancer cell lines and patient-derived xenograft models are the most frequently used models in cancer research and anticancer drug screening. Recently, cancer 'organoid' culture conditions have been developed to establish in vitro growth of patient-derived samples at higher efficiency and they are very promising for large scale drug screening and fundamental cancer biology research. Here, we leverage our experience in prostate cancer to discuss the advantages and limitations of these cancer models and summarize the development of cancer organoid culture--a development which may provide a new path towards personalized medicine in the future. |Animals [MESH] |Drug Screening Assays, Antitumor/*methods [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Male [MESH] |Neoplasms/*drug therapy/*genetics/pathology [MESH] |Organoids/*drug effects [MESH] |Precision Medicine [MESH]Organoid development in cancer genome discovery (epmc).pdf DeepDyve Pubget Overpricing