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10.1111/tra.12258 http://scihub22266oqcxt.onion/10.1111/tra.12258 C5010147!5010147 !25614958     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25614958 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25614958 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Traffic 2015 ; 16 (4 ): 327-337 Nephropedia Template TP {{tp|p=25614958 |t=2015. Organizing polarized delivery of exosomes at synapses |pdf=|usr=}}{{25614958 }} gab.com Text Organizing polarized delivery of exosomes at synapses JO: Traffic http://www.kidney.de/pget.php?&tw=1&pmid=25614958 #FOAvip Exosomes are extracellular vesicles that transport different molecules between cells. They are formed and stored inside multivesicular bodies (MVB) until they are released to the extracellular environment. MVB fuse along the plasma membrane, driving non-polarized secretion of exosomes. However, polarized signaling potentially directs MVBs to a specific point in the plasma membrane to mediate a focal delivery of exosomes. MVB polarization occurs across a broad set of cellular situations, e.g. in immune and neuronal synapses, cell migration and in epithelial sheets. In this review, we summarize the current state of the art of polarized MVB docking and the specification of secretory sites at the plasma membrane. The current view is that MVB positioning and subsequent exosome delivery requires a polarizing, cytoskeletal dependent-trafficking mechanism. In this context, we propose scenarios in which biochemical and mechanical signals could drive the polarized delivery of exosomes in highly polarized cells, such as lymphocytes, neurons and epithelia. Twit Text FOAVip Organizing polarized delivery of exosomes at synapses ????Traffic http://www.kidney.de/pget.php?&tw=1&pmid=25614958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25614958 #FOAvip English Wikipedia <ref>{{Cite pmid|25614958 }}</ref> Organizing polarized delivery of exosomes at synapses #MMPMID25614958 Mittelbrunn M ; Vicente Manzanares M ; Sánchez-Madrid F Traffic 2015[Apr]; 16 (4 ): 327-337 PMID25614958 show ga Exosomes are extracellular vesicles that transport different molecules between cells. They are formed and stored inside multivesicular bodies (MVB) until they are released to the extracellular environment. MVB fuse along the plasma membrane, driving non-polarized secretion of exosomes. However, polarized signaling potentially directs MVBs to a specific point in the plasma membrane to mediate a focal delivery of exosomes. MVB polarization occurs across a broad set of cellular situations, e.g. in immune and neuronal synapses, cell migration and in epithelial sheets. In this review, we summarize the current state of the art of polarized MVB docking and the specification of secretory sites at the plasma membrane. The current view is that MVB positioning and subsequent exosome delivery requires a polarizing, cytoskeletal dependent-trafficking mechanism. In this context, we propose scenarios in which biochemical and mechanical signals could drive the polarized delivery of exosomes in highly polarized cells, such as lymphocytes, neurons and epithelia. |Animals [MESH] |Biological Transport/physiology [MESH] |Cell Membrane/physiology [MESH] |Cell Polarity/*physiology [MESH] |Exosomes/*physiology [MESH] |Humans [MESH]Organizing polarized delivery of exosomes at synapses (epmc).pdf DeepDyve Pubget Overpricing