Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26484042
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Kidney+Res+Clin+Pract
2015 ; 34
(3
): 165-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Organ-on-a-chip and the kidney
#MMPMID26484042
Kim S
; Takayama S
Kidney Res Clin Pract
2015[Sep]; 34
(3
): 165-9
PMID26484042
show ga
Traditional approaches to pathophysiology are advancing but still have many
limitations that arise from real biologic systems and their associated
physiological phenomena being too complicated. Microfluidics is a novel
technology in the field of engineering, which provides new options that may
overcome these hurdles. Microfluidics handles small volumes of fluids and may
apply to various applications such as DNA analysis chips, other lab-on-a-chip
analyses, micropropulsion, and microthermal technologies. Among them,
organ-on-a-chip applications allow the fabrication of minimal functional units of
a single organ or multiple organs. Relevant to the field of nephrology, renal
tubular cells have been integrated with microfluidic devices for making
kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are
showing potential to provide a better understanding of the kidney to replace some
traditional animal and human studies, particularly as more cell types are
incorporated toward the development of a complete glomeruli-on-a-chip.