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2015 ; 7
(9
): a019240
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Organ-Size Regulation in Mammals
#MMPMID26187729
Penzo-Méndez AI
; Stanger BZ
Cold Spring Harb Perspect Biol
2015[Jul]; 7
(9
): a019240
PMID26187729
show ga
The control of organism and organ size is a central question in biology. Despite
the attention it has received, our understanding of how adult organ size is
determined and maintained is still incomplete. Early work has shown that both
autonomous and regulated mechanisms drive vertebrate organ growth, and both
intrinsic and extrinsic cues contribute to organ size. The molecular nature of
organ-size determinants has been the subject of intense study, and major
pathways, which underlie cell interactions controlling cell compartment size,
have been identified. In this work, we review these data as well as the future
perspectives of research in this important area of study.