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10.3346/jkms.2015.30.6.743

http://scihub22266oqcxt.onion/10.3346/jkms.2015.30.6.743
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suck abstract from ncbi


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pmid26028927
      J+Korean+Med+Sci 2015 ; 30 (6 ): 743-8
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  • Organ Correlation in IgG4-Related Diseases #MMPMID26028927
  • Koizumi S ; Kamisawa T ; Kuruma S ; Tabata T ; Chiba K ; Iwasaki S ; Kuwata G ; Fujiwara T ; Fujiwara J ; Arakawa T ; Koizumi K ; Momma K
  • J Korean Med Sci 2015[Jun]; 30 (6 ): 743-8 PMID26028927 show ga
  • IgG4-related disease (IgG4-RD) is a potentially multiorgan disorder. In this study, clinical and serological features from 132 IgG4-RD patients were compared about organ correlations. Underlying pathologies comprised autoimmune pancreatitis (AIP) in 85 cases, IgG4-related sclerosing cholangitis (IgG4-SC) in 12, IgG4-related sialadenitis (IgG4-SIA) in 56, IgG4-related dacryoadenitis (IgG4-DAC) in 38, IgG4-related lymphadenopathy (IgG4-LYM) in 20, IgG4-related retroperitoneal fibrosis (IgG4-RF) in 19, IgG4-related kidney disease (IgG4-KD) in 6, IgG4-related pseudotumor (IgG4-PT) in 3. Sixty-five patients (49%) had multiple IgG4-RD (two affected organs in 36 patients, three in 19, four in 8, five in 1, and six in 1). Serum IgG4 levels were significantly higher with multiple lesions than with a single lesion (P<0.001). The proportion of association with other IgG4-RD was 42% in AIP, the lowest of all IgG4-RDs. Serum IgG4 level was lower in AIP than in other IgG4-RDs. Frequently associated IgG4-RDs were SIA (25%) and DAC (12%) for AIP; AIP (75%) for IgG4-SC; DAC (57%), AIP (38%) and LYM (27%) for IgG4-SIA; AIP (26%) and LYM (26%) for IgG4-DAC; SIA (75%), DAC (50%) and AIP (45%) for IgG4-LYM; SIA (58%), AIP (42%) and LYM (32%) for IgG4-RF; AIP (100%) and SIA (67%) for IgG4-KID; and DAC (67%) and SIA (67%) for IgG4-PT. Most associated IgG4-RD lesions were diagnosed simultaneously, but IgG4-SIA and IgG4-DAC were sometimes identified before other lesions. About half of IgG4-RD patients had multiple IgG4-RD lesions, and some associations were seen between specific organs.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Autoimmune Diseases/*epidemiology/*immunology [MESH]
  • |Comorbidity [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Immunoglobulin G/*immunology [MESH]
  • |Japan/epidemiology [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Multiple Organ Failure/*epidemiology/*immunology [MESH]
  • |Organ Specificity/immunology [MESH]
  • |Prevalence [MESH]
  • |Risk Factors [MESH]


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