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2018 ; 23
(4
): e391-e400
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Oral lesions in Sjogren s syndrome: A systematic review
#MMPMID29924754
Serrano J
; Lopez-Pintor RM
; Gonzalez-Serrano J
; Fernandez-Castro M
; Casanas E
; Hernandez G
Med Oral Patol Oral Cir Bucal
2018[Jul]; 23
(4
): e391-e400
PMID29924754
show ga
BACKGROUND: Sjogren's syndrome (SS) is an autoimmune disease related to two
common symptoms: dry mouth and eyes. Although, xerostomia and hyposialia have
been frequently reported in these patients, not many studies have evaluated other
oral manifestations. The aim of this systematic review was to investigate
prevalence rates of oral lesions (OL) in SS patients and to compare it to a
control group (CG), when available. MATERIAL AND METHODS: An exhaustive search of
the published literature of the Pubmed, Scopus, Web of Science and the Cochrane
Library databases was conducted according to the Preferred Reporting Items for
Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) for relevant studies
that met our eligibility criteria (up to September 1st 2017). RESULTS: Seventeen
cross-sectional studies and one cohort study were finally included. The results
showed that SS patients presented more OL compared to non-SS patients. The most
frequent types of OL registered in primary and secondary SS were angular
cheilitis, atrophic glossitis, recurrent oral ulcerations and grooves or
fissurations of the tongue, also when compared to a CG. CONCLUSIONS: OL are
common and more frequent in SS patients when compared to a CG. This may be a
consequence of low levels of saliva. More studies where these OL and all the
possible cofounding factors are taken into account are needed.