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2015 ; 35
(5
): 506-16
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Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats
#MMPMID25292409
Wakabayashi K
; Hamada C
; Kanda R
; Nakano T
; Io H
; Horikoshi S
; Tomino Y
Perit Dial Int
2015[Sep]; 35
(5
): 506-16
PMID25292409
show ga
BACKGROUND: Preventing peritoneal damage during peritoneal dialysis is critical.
Reactive oxygen species (ROS) have an important role in peritoneal damage;
however, few studies have investigated this. We aimed to determine the effects of
oral astaxanthin (AST) supplementation in a peritoneal fibrosis (PF) rat model.
METHODS: Thirty-seven Sprague-Dawley rats were divided into 5 groups: Control 1
(fed a normal diet without stimulation), Control 2 (fed an AST-supplemented diet
without stimulation), Group 1 (fed a normal diet with 8% chlorhexidine gluconate
[CG] stimulation for 3 weeks), Group 2 (fed a 0.06% AST-supplemented diet with CG
stimulation), and Group 3 (fed a 0.06% AST-supplemented diet that was initiated 4
weeks before CG stimulation). Peritoneal fibrosis, vascular proliferation, and
fibrosis-related factor expression were examined. RESULTS: Peritoneal thickness
was significantly suppressed by AST supplementation. Astaxanthin diminished the
number of CD68-, 8-hydroxy-2'-deoxyguanosine (8-OHdG)-, and monocyte
chemoattractant protein-1 (MCP-1)-positive cells. Type 3 collagen, tumor necrosis
factor-? (TNF-?), interleukin-1? (IL-1?), and MCP-1 mRNA expression was
significantly lower in Group 3 than in Group 1. Increased transforming growth
factor-? (TGF-?) and Snail mRNA expression, vascular density, and the number of
?-smooth muscle actin (?-SMA)-positive cells were also decreased in Group 3.
CONCLUSION: Astaxanthin suppressed PF development through the inhibition of
inflammation and oxidation in PF rats. It appears that the anti-oxidative agent
AST may be useful for the prevention of peritoneal damage.
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