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2015 ; 26
(3
): 226-32
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Optogenetics
#MMPMID25759964
Duebel J
; Marazova K
; Sahel JA
Curr Opin Ophthalmol
2015[May]; 26
(3
): 226-32
PMID25759964
show ga
PURPOSE OF REVIEW: In this review, we will discuss the recent developments in
optogenetics and their potential applications in ophthalmology to restore vision
in retinal degenerative diseases. RECENT FINDINGS: In recent years, we have seen
major advances in the field of optogenetics, providing us with novel opsins for
potential applications in the retina. Microbial opsins with improved light
sensitivity and red-shifted action spectra allow optogenetic stimulation at light
levels well below the safety threshold in the human eye. In parallel, remarkable
success in the development of highly efficient viral vectors for ocular gene
therapy led to new strategies of using these novel optogenetic tools for vision
restoration. SUMMARY: These recent findings show that novel optogenetic tools and
viral vectors for ocular gene delivery are now available providing many
opportunities to develop potential optogenetic strategies for vision restoration.
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