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2017 ; 7
(2
): 71-79
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Optogenetics, Tools and Applications in Neurobiology
#MMPMID28553579
Mahmoudi P
; Veladi H
; Pakdel FG
J Med Signals Sens
2017[Apr]; 7
(2
): 71-79
PMID28553579
show ga
Comprehension of the brain function can be helpful for therapy of
neurodegenerative diseases. The brain consists of various types of neuron sets,
which organize in three-dimensional complex networks and form neural circuits
underlying different behaviors. The circuits act based on the patterns that
encode the brain functions. Recognition of the neural patterns requires methods
to manipulate the neurons. Electrical stimulation may be the most common method.
However, it has significant drawbacks including failure to identify specific
neurons in experiments. As an alternative, optical stimulation is a new method
that acts in combination with genetic approaches. The novel, optogenetic
technology makes it feasible to manipulate either the specific cell types or the
neural circuits. This is associated with minimum tissue damages as well as side
effects. In this study, a new technology has been introduced, and then its
optical and genetical tools have been investigated.
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