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10.1016/j.tibtech.2016.09.002 http://scihub22266oqcxt.onion/10.1016/j.tibtech.2016.09.002 C5316489!5316489 !27692897     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27692897 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Biotechnol 2017 ; 35 (3 ): 215-226 Nephropedia Template TP {{tp|p=27692897 |t=2017. Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity |pdf=|usr=}}{{27692897 }} gab.com Text Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity JO: Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27692897 #FOAvip Microbial opsin-based optogenetic tools have been transformative for neuroscience. To extend optogenetic approaches to the immune system to remotely control immune responses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate lymphocyte trafficking, inflammasome activation, dendritic cell (DC) maturation, and antitumor immunity through the photoactivation of engineered chemokine receptors and calcium release-activated calcium channels. We highlight herein some conceptual design strategies for installing light sensitivities into the immune signaling network and, in parallel, we propose potential solutions for in vivo optogenetic applications in living organisms with near-infrared light-responsive upconversion nanomaterials. Moreover, to move beyond proof-of-concept into translational applications, we discuss future prospects for integrating personalized immunoengineering with optogenetics to overcome critical hurdles in cancer immunotherapy. Twit Text FOAVip Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity ????Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=27692897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27692897 #FOAvip English Wikipedia <ref>{{Cite pmid|27692897 }}</ref> Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity #MMPMID27692897 Tan P ; He L ; Han G ; Zhou Y Trends Biotechnol 2017[Mar]; 35 (3 ): 215-226 PMID27692897 show ga Microbial opsin-based optogenetic tools have been transformative for neuroscience. To extend optogenetic approaches to the immune system to remotely control immune responses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate lymphocyte trafficking, inflammasome activation, dendritic cell (DC) maturation, and antitumor immunity through the photoactivation of engineered chemokine receptors and calcium release-activated calcium channels. We highlight herein some conceptual design strategies for installing light sensitivities into the immune signaling network and, in parallel, we propose potential solutions for in vivo optogenetic applications in living organisms with near-infrared light-responsive upconversion nanomaterials. Moreover, to move beyond proof-of-concept into translational applications, we discuss future prospects for integrating personalized immunoengineering with optogenetics to overcome critical hurdles in cancer immunotherapy. |*Bioengineering [MESH] |*Immunomodulation [MESH] |*Neoplasms/drug therapy/immunology [MESH] |*Optogenetics [MESH] |Animals [MESH] |Humans [MESH]Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity (epmc).pdf DeepDyve Pubget Overpricing