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10.1073/pnas.1402724111 http://scihub22266oqcxt.onion/10.1073/pnas.1402724111 C4260541!4260541 !25411315     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25411315 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (48 ): 17248-53 Nephropedia Template TP {{tp|p=25411315 |t=2014. Optimal T-cell receptor affinity for inducing autoimmunity |pdf=|usr=}}{{25411315 }} gab.com Text Optimal T-cell receptor affinity for inducing autoimmunity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip T-cell receptor affinity for self-antigen has an important role in establishing self-tolerance. Three transgenic mouse strains expressing antigens of variable affinity for the OVA transgenic-I T-cell receptor were generated to address how TCR affinity affects the efficiency of negative selection, the ability to prime an autoimmune response, and the elimination of the relevant target cell. Mice expressing antigens with an affinity just above the negative selection threshold exhibited the highest risk of developing experimental autoimmune diabetes. The data demonstrate that close to the affinity threshold for negative selection, sufficient numbers of self-reactive T cells escape deletion and create an increased risk for the development of autoimmunity. Twit Text FOAVip Optimal T-cell receptor affinity for inducing autoimmunity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip English Wikipedia <ref>{{Cite pmid|25411315 }}</ref> Optimal T-cell receptor affinity for inducing autoimmunity #MMPMID25411315 Koehli S ; Naeher D ; Galati-Fournier V ; Zehn D ; Palmer E Proc Natl Acad Sci U S A 2014[Dec]; 111 (48 ): 17248-53 PMID25411315 show ga T-cell receptor affinity for self-antigen has an important role in establishing self-tolerance. Three transgenic mouse strains expressing antigens of variable affinity for the OVA transgenic-I T-cell receptor were generated to address how TCR affinity affects the efficiency of negative selection, the ability to prime an autoimmune response, and the elimination of the relevant target cell. Mice expressing antigens with an affinity just above the negative selection threshold exhibited the highest risk of developing experimental autoimmune diabetes. The data demonstrate that close to the affinity threshold for negative selection, sufficient numbers of self-reactive T cells escape deletion and create an increased risk for the development of autoimmunity. |Animals [MESH] |Autoantigens/*immunology/metabolism [MESH] |Autoimmunity/genetics/*immunology [MESH] |Binding, Competitive/immunology [MESH] |Diabetes Mellitus, Type 1/genetics/immunology/metabolism [MESH] |Flow Cytometry [MESH] |Insulin-Secreting Cells/immunology/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Ovalbumin/genetics/immunology/metabolism [MESH] |Protein Binding/immunology [MESH] |Receptors, Antigen, T-Cell/*immunology/metabolism [MESH] |Self Tolerance/genetics/immunology [MESH]Optimal T-cell receptor affinity for inducing autoimmunity (epmc).pdf DeepDyve Pubget Overpricing