Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-018-03233-9 http://scihub22266oqcxt.onion/10.1038/s41467-018-03233-9 C5920064!5920064 !29700283     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29700283 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29700283 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 1680 Nephropedia Template TP {{tp|p=29700283 |t=2018. Optically-controlled bacterial metabolite for cancer therapy |pdf=|usr=}}{{29700283 }} gab.com Text Optically-controlled bacterial metabolite for cancer therapy JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29700283 #FOAvip Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully satisfy the requirements on both stability and high efficiency. Here, we propose a strategy of "charging" bacteria with a nano-photocatalyst to strengthen their metabolic activities. Carbon nitride (C(3)N(4)) is combined with Escherichia coli (E. coli) carrying nitric oxide (NO) generation enzymes for photo-controlled bacterial metabolite therapy (PMT). Under light irradiation, photoelectrons produced by C(3)N(4) can be transferred to E. coli to promote the enzymatic reduction of endogenous NO(3)(-) to cytotoxic NO with a 37-fold increase. In a mouse model, C(3)N(4) loaded bacteria are perfectly accumulated throughout the tumor and the PMT treatment results in around 80% inhibition of tumor growth. Thus, synthetic materials-remodeled microorganism may be used to regulate focal microenvironments and increase therapeutic efficiency. Twit Text FOAVip Optically-controlled bacterial metabolite for cancer therapy ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29700283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29700283 #FOAvip English Wikipedia <ref>{{Cite pmid|29700283 }}</ref> Optically-controlled bacterial metabolite for cancer therapy #MMPMID29700283 Zheng DW ; Chen Y ; Li ZH ; Xu L ; Li CX ; Li B ; Fan JX ; Cheng SX ; Zhang XZ Nat Commun 2018[Apr]; 9 (1 ): 1680 PMID29700283 show ga Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully satisfy the requirements on both stability and high efficiency. Here, we propose a strategy of "charging" bacteria with a nano-photocatalyst to strengthen their metabolic activities. Carbon nitride (C(3)N(4)) is combined with Escherichia coli (E. coli) carrying nitric oxide (NO) generation enzymes for photo-controlled bacterial metabolite therapy (PMT). Under light irradiation, photoelectrons produced by C(3)N(4) can be transferred to E. coli to promote the enzymatic reduction of endogenous NO(3)(-) to cytotoxic NO with a 37-fold increase. In a mouse model, C(3)N(4) loaded bacteria are perfectly accumulated throughout the tumor and the PMT treatment results in around 80% inhibition of tumor growth. Thus, synthetic materials-remodeled microorganism may be used to regulate focal microenvironments and increase therapeutic efficiency. |*Biological Therapy [MESH] |Animals [MESH] |Apoptosis [MESH] |Cell Line, Tumor [MESH] |Escherichia coli/enzymology/genetics/*metabolism/*radiation effects [MESH] |Female [MESH] |Humans [MESH] |Light [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Neoplasms/metabolism/microbiology/*therapy [MESH] |Nitric Oxide/metabolism [MESH] |Nitriles/*chemistry [MESH] |Oxidative Stress [MESH]Optically-controlled bacterial metabolite for cancer therapy (epmc).pdf DeepDyve Pubget Overpricing