Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28271003
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28271003
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomed+Opt+Express
2017 ; 8
(2
): 1056-1082
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Optical coherence tomography based angiography Invited
#MMPMID28271003
Chen CL
; Wang RK
Biomed Opt Express
2017[Feb]; 8
(2
): 1056-1082
PMID28271003
show ga
Optical coherence tomography (OCT)-based angiography (OCTA) provides in vivo,
three-dimensional vascular information by the use of flowing red blood cells as
intrinsic contrast agents, enabling the visualization of functional vessel
networks within microcirculatory tissue beds non-invasively, without a need of
dye injection. Because of these attributes, OCTA has been rapidly translated to
clinical ophthalmology within a short period of time in the development. Various
OCTA algorithms have been developed to detect the functional micro-vasculatures
in vivo by utilizing different components of OCT signals, including
phase-signal-based OCTA, intensity-signal-based OCTA and complex-signal-based
OCTA. All these algorithms have shown, in one way or another, their clinical
values in revealing micro-vasculatures in biological tissues in vivo, identifying
abnormal vascular networks or vessel impairment zones in retinal and skin
pathologies, detecting vessel patterns and angiogenesis in eyes with age-related
macular degeneration and in skin and brain with tumors, and monitoring responses
to hypoxia in the brain tissue. The purpose of this paper is to provide a
technical oriented overview of the OCTA developments and their potential
pre-clinical and clinical applications, and to shed some lights on its future
perspectives. Because of its clinical translation to ophthalmology, this review
intentionally places a slightly more weight on ophthalmic OCT angiography.