Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24700701
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24700701
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biophotonics
2015 ; 8
(5
): 372-81
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Optical Thromboelastography to evaluate whole blood coagulation
#MMPMID24700701
Hajjarian Z
; Tripathi MM
; Nadkarni SK
J Biophotonics
2015[May]; 8
(5
): 372-81
PMID24700701
show ga
Measurement of blood viscoelasticity during clotting provides a direct metric of
haemostatic conditions. Therefore, technologies that quantify blood
viscoelasticity at the point-of-care are invaluable for diagnosing
coagulopathies. We present a new approach, Optical Thromboelastography (OTEG)
that measures the viscoelastic properties of coagulating blood by evaluating
temporal laser speckle fluctuations, reflected from a few blood drops. During
coagulation, platelet-fibrin clot formation restricts the mean square
displacements (MSD) of scatterers and decelerates speckle fluctuations.
Cross-correlation analysis of speckle frames provides the speckle intensity
temporal autocorrelation, g2 (t), from which MSD is deduced and the viscoelastic
modulus of blood is estimated. Our results demonstrate a close correspondence
between blood viscoelasticity evaluated by OTEG and mechanical rheometry.
Spatio-temporal speckle analyses yield 2-dimensional maps of clot
viscoelasticity, enabling the identification of micro-clot formation at distinct
rates in normal and coagulopathic specimens. These findings confirm the unique
capability of OTEG for the rapid evaluation of patients' coagulation status and
highlight the potential for point-of-care use.