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2016 ; 57
(11
): 1661-1666
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Optical Imaging of Ionizing Radiation from Clinical Sources
#MMPMID27688469
Shaffer TM
; Drain CM
; Grimm J
J Nucl Med
2016[Nov]; 57
(11
): 1661-1666
PMID27688469
show ga
Nuclear medicine uses ionizing radiation for both in vivo diagnosis and therapy.
Ionizing radiation comes from a variety of sources, including x-rays, beam
therapy, brachytherapy, and various injected radionuclides. Although PET and
SPECT remain clinical mainstays, optical readouts of ionizing radiation offer
numerous benefits and complement these standard techniques. Furthermore, for
ionizing radiation sources that cannot be imaged using these standard techniques,
optical imaging offers a unique imaging alternative. This article reviews optical
imaging of both radionuclide- and beam-based ionizing radiation from high-energy
photons and charged particles through mechanisms including radioluminescence,
Cerenkov luminescence, and scintillation. Therapeutically, these visible photons
have been combined with photodynamic therapeutic agents preclinically for
increasing therapeutic response at depths difficult to reach with external light
sources. Last, new microscopy methods that allow single-cell optical imaging of
radionuclides are reviewed.