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10.1021/ja512664v http://scihub22266oqcxt.onion/10.1021/ja512664v C4919123!4919123 !25905628     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25905628 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Chem+Soc 2015 ; 137 (17 ): 5642-5 Nephropedia Template TP {{tp|p=25905628 |t=2015. Optical Control of CRISPR/Cas9 Gene Editing |pdf=|usr=}}{{25905628 }} gab.com Text Optical Control of CRISPR/Cas9 Gene Editing JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=25905628 #FOAvip The CRISPR/Cas9 system has emerged as an important tool in biomedical research for a wide range of applications, with significant potential for genome engineering and gene therapy. In order to achieve conditional control of the CRISPR/Cas9 system, a genetically encoded light-activated Cas9 was engineered through the site-specific installation of a caged lysine amino acid. Several potential lysine residues were identified as viable caging sites that can be modified to optically control Cas9 function, as demonstrated through optical activation and deactivation of both exogenous and endogenous gene function. Twit Text FOAVip Optical Control of CRISPR/Cas9 Gene Editing ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=25905628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25905628 #FOAvip English Wikipedia <ref>{{Cite pmid|25905628 }}</ref> Optical Control of CRISPR/Cas9 Gene Editing #MMPMID25905628 Hemphill J ; Borchardt EK ; Brown K ; Asokan A ; Deiters A J Am Chem Soc 2015[May]; 137 (17 ): 5642-5 PMID25905628 show ga The CRISPR/Cas9 system has emerged as an important tool in biomedical research for a wide range of applications, with significant potential for genome engineering and gene therapy. In order to achieve conditional control of the CRISPR/Cas9 system, a genetically encoded light-activated Cas9 was engineered through the site-specific installation of a caged lysine amino acid. Several potential lysine residues were identified as viable caging sites that can be modified to optically control Cas9 function, as demonstrated through optical activation and deactivation of both exogenous and endogenous gene function. |*Genetic Engineering [MESH] |CRISPR-Cas Systems/*genetics [MESH] |Clustered Regularly Interspaced Short Palindromic Repeats/*genetics [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Lysine/chemistry/genetics [MESH] |Models, Molecular [MESH] |Molecular Structure [MESH]Optical Control of CRISPR/Cas9 Gene Editing (epmc).pdf DeepDyve Pubget Overpricing