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2016 ; 61
(6
): 745-758
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Optic disk drusen in children
#MMPMID27033945
Chang MY
; Pineles SL
Surv Ophthalmol
2016[Nov]; 61
(6
): 745-758
PMID27033945
show ga
Optic disk drusen occur in 0.4% of children and consist of acellular
intracellular and extracellular deposits that often become calcified over time.
They are typically buried early in life and generally become superficial, and
therefore visible, later in childhood, at the average age of 12 years. Their main
clinical significance lies in the ability of optic disk drusen, particularly when
buried, to simulate true optic disk edema. Misdiagnosing drusen as true disk
edema may lead to an invasive and unnecessary workup for elevated intracranial
pressure. Ancillary testing, including ultrasonography, fluorescein angiography,
fundus autofluorescence, and optical coherence tomography, may aid in the correct
diagnosis of optic disk drusen. Complications of optic disk drusen in children
include visual field defects, hemorrhages, choroidal neovascular membrane,
nonarteritic anterior ischemic optic neuropathy, and retinal vascular occlusions.
Treatment options for these complications include ocular hypotensive agents for
visual field defects and intravitreal anti-vascular endothelial growth factor
agents for choroidal neovascular membranes. In most cases, however, children with
optic disk drusen can be managed by observation with serial examinations and
visual field testing once true optic disk edema has been excluded.
|*Optic Disk Drusen/diagnosis/epidemiology/physiopathology
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