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2016 ; 7
(2
): 121-34
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Opioid-induced constipation: advances and clinical guidance
#MMPMID26977281
Nelson AD
; Camilleri M
Ther Adv Chronic Dis
2016[Mar]; 7
(2
): 121-34
PMID26977281
show ga
Currently opioids are the most frequently used medications for chronic noncancer
pain. Opioid-induced constipation is the most common adverse effect associated
with prolonged use of opioids, having a major impact on quality of life. There is
an increasing need to treat opioid-induced constipation. With the recent approval
of medications for the treatment of opioid-induced constipation, there are
several therapeutic approaches. This review addresses the clinical presentation
and diagnosis of opioid-induced constipation, barriers to its diagnosis, effects
of opioids in the gastrointestinal tract, differential tolerance to opiates in
different gastrointestinal organs, medications approved and in development for
the treatment of opioid-induced constipation, and a proposed clinical management
algorithm for treating opioid-induced constipation in patients with noncancer
pain.