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2016 ; 1
(1
): 5-13
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Opioid System Modulates the Immune Function: A Review
#MMPMID26985446
Liang X
; Liu R
; Chen C
; Ji F
; Li T
Transl Perioper Pain Med
2016[]; 1
(1
): 5-13
PMID26985446
show ga
Opioid receptors and their ligands produce powerful analgesia that is effective
in perioperative period and chronic pain managements accompanied with various
side effects including respiratory depression, constipation and addiction etc.
Opioids can also interfere with the immune system, not only participating in the
function of the immune cells, but also modulating innate and acquired immune
responses. The traditional notion of opioids is immunosuppressive. Recent studies
indicate that the role of opioid receptors on immune function is complicated,
working through various different mechanisms. Different opioids or opioids
administrations show various effects on the immune system: immunosuppressive,
immunostimulatory, or dual effect. It is important to elucidate the relationship
between opioids and immune function, since immune system plays critical role in
various physiological and pathophysiological processes, including the
inflammation, tumor growth and metastasis, drug abuse, and so on. This review
article tends to have an overview of the recent work and perspectives on opioids
and the immune function.
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