Opiate pharmacology and relief of pain
#MMPMID24799496
Pasternak GW
J Clin Oncol
2014[Jun]; 32
(16
): 1655-61
PMID24799496
show ga
Opioids remain the mainstay of severe pain management in patients with cancer.
The hallmark of pain management is individualization of therapy. Although almost
all clinically used drugs act through mu opioid receptors, they display subtle
but important differences pharmacologically. Furthermore, not all patients
respond equally well to all drugs. Evidence suggests that these variable
responses among patients have a biologic basis and are likely to involve both
biased agonism and the many mu opioid receptor subtypes that have been cloned.
|Analgesics, Opioid/*pharmacology/*therapeutic use
[MESH]
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