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2016 ; 5
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English Wikipedia
Oocyte Maturation and Development
#MMPMID26998245
Verlhac MH
; Terret ME
F1000Res
2016[]; 5
(ä): ä PMID26998245
show ga
Sexual reproduction is essential for many organisms to propagate themselves. It
requires the formation of haploid female and male gametes: oocytes and sperms.
These specialized cells are generated through meiosis, a particular type of cell
division that produces cells with recombined genomes that differ from their
parental origin. In this review, we highlight the end process of female meiosis,
the divisions per se, and how they can give rise to a functional female gamete
preparing itself for the ensuing zygotic development. In particular, we discuss
why such an essential process in the propagation of species is so poorly
controlled, producing a strong percentage of abnormal female gametes in the end.
Eventually, we examine aspects related to the lack of centrosomes in female
oocytes, the asymmetry in size of the mammalian oocyte upon division, and in
mammals the direct consequences of these long-lived cells in the ovary.