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10.3389/fimmu.2015.00486 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00486 C4585135!4585135 !26441990     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26441990 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2015 ; 6 (ä): 486 Nephropedia Template TP {{tp|p=26441990 |t=2015. Ontogeny of Tissue-Resident Macrophages |pdf=|usr=}}{{26441990 }} gab.com Text Ontogeny of Tissue-Resident Macrophages JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26441990 #FOAvip The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb(+) EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations. Twit Text FOAVip Ontogeny of Tissue-Resident Macrophages ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26441990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26441990 #FOAvip English Wikipedia <ref>{{Cite pmid|26441990 }}</ref> Ontogeny of Tissue-Resident Macrophages #MMPMID26441990 Hoeffel G ; Ginhoux F Front Immunol 2015[]; 6 (ä): 486 PMID26441990 show ga The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb(+) EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations. äOntogeny of Tissue-Resident Macrophages (epmc).pdf DeepDyve Pubget Overpricing