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Br J Cancer
2017[Jun]; 116
(12
): 1499-1504
PMID28472819
show ga
Cells require one-carbon units for nucleotide synthesis, methylation and
reductive metabolism, and these pathways support the high proliferative rate of
cancer cells. As such, anti-folates, drugs that target one-carbon metabolism,
have long been used in the treatment of cancer. Amino acids, such as serine are a
major one-carbon source, and cancer cells are particularly susceptible to
deprivation of one-carbon units by serine restriction or inhibition of de novo
serine synthesis. Recent work has also begun to decipher the specific pathways
and sub-cellular compartments that are important for one-carbon metabolism in
cancer cells. In this review we summarise the historical understanding of
one-carbon metabolism in cancer, describe the recent findings regarding the
generation and usage of one-carbon units and explore possible future therapeutics
that could exploit the dependency of cancer cells on one-carbon metabolism.
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