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10.1016/j.stemcr.2015.12.012 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.12.012 C4788754!4788754 !26876667     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26876667 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cell+Reports 2016 ; 6 (3 ): 273-83 Nephropedia Template TP {{tp|p=26876667 |t=2016. Oncometabolic Nuclear Reprogramming of Cancer Stemness |pdf=|usr=}}{{26876667 }} gab.com Text Oncometabolic Nuclear Reprogramming of Cancer Stemness JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26876667 #FOAvip By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. Our biomathematical model, which introduces nucleosome modification and epigenetic regulation of cell differentiation genes to account for the direct effects of oncometabolites on nuclear reprogramming, demonstrates that oncometabolites markedly lower the "energy barriers" separating non-stem and stem cell attractors, diminishes the average time of nuclear reprogramming, and increases the size of the basin of attraction of the macrostate occupied by stem cells. These findings establish the concept of oncometabolic nuclear reprogramming of stemness as a bona fide metabolo-epigenetic mechanism for generation of cancer stem-like cells. Twit Text FOAVip Oncometabolic Nuclear Reprogramming of Cancer Stemness ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26876667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26876667 #FOAvip English Wikipedia <ref>{{Cite pmid|26876667 }}</ref> Oncometabolic Nuclear Reprogramming of Cancer Stemness #MMPMID26876667 Menendez JA ; Corominas-Faja B ; Cuyàs E ; García MG ; Fernández-Arroyo S ; Fernández AF ; Joven J ; Fraga MF ; Alarcón T Stem Cell Reports 2016[Mar]; 6 (3 ): 273-83 PMID26876667 show ga By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. Our biomathematical model, which introduces nucleosome modification and epigenetic regulation of cell differentiation genes to account for the direct effects of oncometabolites on nuclear reprogramming, demonstrates that oncometabolites markedly lower the "energy barriers" separating non-stem and stem cell attractors, diminishes the average time of nuclear reprogramming, and increases the size of the basin of attraction of the macrostate occupied by stem cells. These findings establish the concept of oncometabolic nuclear reprogramming of stemness as a bona fide metabolo-epigenetic mechanism for generation of cancer stem-like cells. |*Cellular Reprogramming [MESH] |Epigenesis, Genetic [MESH] |Epithelial Cells/cytology/metabolism [MESH] |Histones/metabolism [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Methylation [MESH] |Models, Biological [MESH] |Neoplastic Stem Cells/*cytology/metabolism [MESH]Oncometabolic Nuclear Reprogramming of Cancer Stemness (epmc).pdf DeepDyve Pubget Overpricing