Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25685829
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Genes+Dis
2014 ; 1
(2
): 214-226
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Oncolytic adenoviruses: A thorny path to glioma cure
#MMPMID25685829
Ulasov IV
; Borovjagin AV
; Schroeder BA
; Baryshnikov AY
Genes Dis
2014[Dec]; 1
(2
): 214-226
PMID25685829
show ga
Glioblastoma Multiforme (GBM) is a rapidly progressing brain tumor. Despite the
relatively low percentage of cancer patients with glioma diagnoses, recent
statistics indicate that the number of glioma patients may have increased over
the past decade. Current therapeutic options for glioma patients include tumor
resection, chemotherapy, and concomitant radiation therapy with an average
survival of approximately 16 months. The rapid progression of gliomas has spurred
the development of novel treatment options, such as cancer gene therapy and
oncolytic virotherapy. Preclinical testing of oncolytic adenoviruses using glioma
models revealed both positive and negative sides of the virotherapy approach.
Here we present a detailed overview of the glioma virotherapy field and discuss
auxiliary therapeutic strategies with the potential for augmenting clinical
efficacy of GBM virotherapy treatment.