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2017 ; 8
(16
): 27661-27672
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Oncogenic senescence: a multi-functional perspective
#MMPMID28416761
Baker DJ
; Alimirah F
; van Deursen JM
; Campisi J
; Hildesheim J
Oncotarget
2017[Apr]; 8
(16
): 27661-27672
PMID28416761
show ga
Cellular senescence is defined as an irreversible growth arrest with the
acquisition of a distinctive secretome. The growth arrest is a potent anticancer
mechanism whereas the secretome facilitates wound healing, tissue repair, and
development. The senescence response has also become increasingly recognized as
an important contributor to aging and age-related diseases, including cancer.
Although oncogenic mutations are capable of inducing a beneficial senescence
response that prevents the growth of premalignant cells and promotes cancer
immune-surveillance, the secretome of senescent cells also includes factors with
pro-tumorigenic properties. On June 23rd and 24th, 2016, the Division of Cancer
Biology of the National Cancer Institute sponsored a workshop to discuss the
complex role of cellular senescence in tumorigenesis with the goal to define the
major challenges and opportunities within this important field of cancer
research. Additionally, it was noted how the development of novel tools and
technologies are required to accelerate research into a mechanistic understanding
of senescent cells in carcinogenesis in order to overcome the current limitations
in this exciting, yet ill-defined area.
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