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10.1111/cas.13173 http://scihub22266oqcxt.onion/10.1111/cas.13173 C5406539!5406539 !28109176     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28109176 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2017 ; 108 (4 ): 547-552 Nephropedia Template TP {{tp|p=28109176 |t=2017. Oncogenic roles of SMARCB1/INI1 and its deficient tumors |pdf=|usr=}}{{28109176 }} gab.com Text Oncogenic roles of SMARCB1/INI1 and its deficient tumors JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28109176 #FOAvip SMARCB1/INI1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. Interactions have been demonstrated between SMARCB1/INI1 and key proteins in various pathways related to tumor proliferation and progression: the p16-RB pathway, WNT signaling pathway, sonic hedgehog signaling pathway and Polycomb pathway. Initially, no detectable SMARCB1/INI1 protein expression was found in malignant rhabdoid tumor cells, whereas all other kinds of tumor cells and non-tumorous tissue showed SMARCB1/INI1 protein expression. Therefore, immunohistochemical testing for the SMARCB1/INI1 antibody has been considered useful in confirming the histologic diagnosis of malignant rhabdoid tumors. However, recently, aberrant expression of SMARCB1/INI1 has been found in various tumors such as epithelioid sarcomas, schwannomatosis, synovial sarcomas, and so on. In addition, it has been reported that aberrant expression can be classified into three patterns: complete loss, mosaic expression and reduced expression. Although the various pathways related to mechanisms of tumorigenesis and tumor proliferation are complexly intertwined, the clarification of these mechanisms may contribute to therapeutic strategies in SMARCB1/INI1-deficient tumors. In terms of pathological classifications, SMARCB1/INI1-deficient tumors may be re-classified by genetic backgrounds. Twit Text FOAVip Oncogenic roles of SMARCB1/INI1 and its deficient tumors ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28109176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28109176 #FOAvip English Wikipedia <ref>{{Cite pmid|28109176 }}</ref> Oncogenic roles of SMARCB1/INI1 and its deficient tumors #MMPMID28109176 Kohashi K ; Oda Y Cancer Sci 2017[Apr]; 108 (4 ): 547-552 PMID28109176 show ga SMARCB1/INI1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. Interactions have been demonstrated between SMARCB1/INI1 and key proteins in various pathways related to tumor proliferation and progression: the p16-RB pathway, WNT signaling pathway, sonic hedgehog signaling pathway and Polycomb pathway. Initially, no detectable SMARCB1/INI1 protein expression was found in malignant rhabdoid tumor cells, whereas all other kinds of tumor cells and non-tumorous tissue showed SMARCB1/INI1 protein expression. Therefore, immunohistochemical testing for the SMARCB1/INI1 antibody has been considered useful in confirming the histologic diagnosis of malignant rhabdoid tumors. However, recently, aberrant expression of SMARCB1/INI1 has been found in various tumors such as epithelioid sarcomas, schwannomatosis, synovial sarcomas, and so on. In addition, it has been reported that aberrant expression can be classified into three patterns: complete loss, mosaic expression and reduced expression. Although the various pathways related to mechanisms of tumorigenesis and tumor proliferation are complexly intertwined, the clarification of these mechanisms may contribute to therapeutic strategies in SMARCB1/INI1-deficient tumors. In terms of pathological classifications, SMARCB1/INI1-deficient tumors may be re-classified by genetic backgrounds. |*Gene Expression Regulation, Neoplastic [MESH] |Biomarkers, Tumor/genetics/metabolism [MESH] |Carcinogenesis/genetics [MESH] |Cell Proliferation/genetics [MESH] |Disease Progression [MESH] |Humans [MESH] |Oncogenes/genetics [MESH] |Rhabdoid Tumor/diagnosis/*genetics/metabolism [MESH] |SMARCB1 Protein/deficiency/*genetics/metabolism [MESH]Oncogenic roles of SMARCB1/INI1 and its deficient tumors (epmc).pdf DeepDyve Pubget Overpricing