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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2015 ; 6
(18
): 15772-87
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Oncogenic cancer/testis antigens: prime candidates for immunotherapy
#MMPMID26158218
Gjerstorff MF
; Andersen MH
; Ditzel HJ
Oncotarget
2015[Jun]; 6
(18
): 15772-87
PMID26158218
show ga
Recent developments have set the stage for immunotherapy as a supplement to
conventional cancer treatment. Consequently, a significant effort is required to
further improve efficacy and specificity, particularly the identification of
optimal therapeutic targets for clinical testing. Cancer/testis antigens are
immunogenic, highly cancer-specific, and frequently expressed in various types of
cancer, which make them promising candidate targets for cancer immunotherapy,
including cancer vaccination and adoptive T-cell transfer with chimeric T-cell
receptors. Our current understanding of tumor immunology and immune escape
suggests that targeting oncogenic antigens may be beneficial, meaning that
identification of cancer/testis antigens with oncogenic properties is of high
priority. Recent work from our lab and others provide evidence that many
cancer/testis antigens, in fact, have oncogenic functions, including support of
growth, survival and metastasis. This novel insight into the function of
cancer/testis antigens has the potential to deliver more effective cancer
vaccines. Moreover, immune targeting of oncogenic cancer/testis antigens in
combination with conventional cytotoxic therapies or novel immunotherapies such
as checkpoint blockade or adoptive transfer, represents a highly synergistic
approach with the potential to improve patient survival.