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10.18632/oncotarget.4694

http://scihub22266oqcxt.onion/10.18632/oncotarget.4694
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suck abstract from ncbi


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pmid26158218
      Oncotarget 2015 ; 6 (18 ): 15772-87
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  • Oncogenic cancer/testis antigens: prime candidates for immunotherapy #MMPMID26158218
  • Gjerstorff MF ; Andersen MH ; Ditzel HJ
  • Oncotarget 2015[Jun]; 6 (18 ): 15772-87 PMID26158218 show ga
  • Recent developments have set the stage for immunotherapy as a supplement to conventional cancer treatment. Consequently, a significant effort is required to further improve efficacy and specificity, particularly the identification of optimal therapeutic targets for clinical testing. Cancer/testis antigens are immunogenic, highly cancer-specific, and frequently expressed in various types of cancer, which make them promising candidate targets for cancer immunotherapy, including cancer vaccination and adoptive T-cell transfer with chimeric T-cell receptors. Our current understanding of tumor immunology and immune escape suggests that targeting oncogenic antigens may be beneficial, meaning that identification of cancer/testis antigens with oncogenic properties is of high priority. Recent work from our lab and others provide evidence that many cancer/testis antigens, in fact, have oncogenic functions, including support of growth, survival and metastasis. This novel insight into the function of cancer/testis antigens has the potential to deliver more effective cancer vaccines. Moreover, immune targeting of oncogenic cancer/testis antigens in combination with conventional cytotoxic therapies or novel immunotherapies such as checkpoint blockade or adoptive transfer, represents a highly synergistic approach with the potential to improve patient survival.
  • |Antigens, Neoplasm/*immunology [MESH]
  • |Humans [MESH]
  • |Immunotherapy/*methods [MESH]
  • |Male [MESH]
  • |Neoplasms/*immunology/*therapy [MESH]


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