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2015 ; 5
(ä): 14571
Nephropedia Template TP
Patra HK
; Imani R
; Jangamreddy JR
; Pazoki M
; Igli? A
; Turner AP
; Tiwari A
Sci Rep
2015[Sep]; 5
(ä): 14571
PMID26415561
show ga
Throughout the world, there are increasing demands for alternate approaches to
advanced cancer therapeutics. Numerous potentially chemotherapeutic compounds are
developed every year for clinical trial and some of them are considered as
potential drug candidates. Nanotechnology-based approaches have accelerated the
discovery process, but the key challenge still remains to develop therapeutically
viable and physiologically safe materials suitable for cancer therapy. Here, we
report a high turnover, on/off-switchable functionally popping reactive oxygen
species (ROS) generator using a smart mesoporous titanium dioxide popcorn (TiO2
Pops) nanoarchitecture. The resulting TiO2 Pops, unlike TiO2 nanoparticles (TiO2
NPs), are exceptionally biocompatible with normal cells. Under identical
conditions, TiO2 Pops show very high photocatalytic activity compared to TiO2
NPs. Upon on/off-switchable photo activation, the TiO2 Pops can trigger the
generation of high-turnover flash ROS and can deliver their potential anticancer
effect by enhancing the intracellular ROS level until it crosses the threshold to
open the 'death gate', thus reducing the survival of cancer cells by at least six
times in comparison with TiO2 NPs without affecting the normal cells.
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