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Transl Androl Urol
2018[Feb]; 7
(1
): 145-154
PMID29594028
show ga
The management of newly diagnosed prostate cancer is challenging because of its
heterogeneity in histology, genetics and clinical outcome. The clinical outcome
of patients with Gleason score 7 prostate cancer varies greatly. Improving risk
assessment in this group is of particular interest, as Gleason score 7 prostate
cancer on biopsy is an important clinical threshold for active treatment.
Architecturally, four Gleason grade 4 growth patterns are recognized: ill-formed,
fused, glomeruloid and cribriform. The aim of this review is to describe the role
of cribriform growth in prostate cancer with respect to diagnosis, prognosis and
molecular pathology. Secondly, we will discuss clinical applications for
cribriform prostate cancer and give recommendations for future research.
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