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1992 ; 83
(1
): 6-9
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Okadaic acid is a potent angiogenesis inducer
#MMPMID1371991
Oikawa T
; Suganuma M
; Ashino-Fuse H
; Shimamura M
Jpn J Cancer Res
1992[Jan]; 83
(1
): 6-9
PMID1371991
show ga
Okadaic acid, which is a non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type
tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced
angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent
angiogenic activity was dose-dependent. The minimum effective dose was 5 fmol/egg
and the effective dose for 50% induction was 90 fmol/egg. These results indicated
that okadaic acid exhibits angiogenic activity one order of magnitude stronger
than that of TPA (reported previously). Moreover, the time-course of angiogenesis
induction by okadaic acid was much slower than that by TPA. The difference is
consistent with the time-courses of other biochemical and biological activities
and also various gene expressions induced by okadaic acid and TPA, indicating
that the difference in the time-course is associated with their mechanisms of
action. We conclude that okadaic acid induces angiogenesis through a different
pathway than does TPA, indicating the existence of a new mechanism of
angiogenesis induction.
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