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Ocular syphilis: an alarming infectious eye disease
#MMPMID26221328
Shen J
; Feng L
; Li Y
Int J Clin Exp Med
2015[]; 8
(5
): 7770-7
PMID26221328
show ga
BACKGROUND: To describe the clinical manifestations and ancillary examination
outcomes of ocular syphilis in Southeast China. MATERIALS AND METHODS: This is a
retrospective, nonrandom case study. Demographic information, serum and
cerebrospinal fluid (CSF) test results, and findings of fundus fluorescein
angiography (FFA), indocyanine green angiography (ICGA), and spectral domain
optical coherence tomography (SD-OCT) were analyzed. RESULTS: The study examined
21 eyes of 13 patients (average age 50.3 ± 5.9 (range 37-61) years). HIV
co-infection was found in one patient. The most common manifestation was
chorioretinitis (52.4%). Disc hyperfluorescence (66.7%) and persistent dark spots
(91.7%) were the most common findings on FFA and ICGA, respectively. The inner
segment/outer segment junction (IS/OS) loss was the most frequent manifestation
(86.7%). Among the six patients with confirmed neurosyphilis, the average CSF
protein level was 528.8 ± 327.1 mg/L. Visual acuity (VA) was improved in 8 of 13
eyes (61.5%) after treatment. CONCLUSIONS: The manifestations of ocular syphilis
can mimic any eye disease. Chorioretinitis was the most common finding in this
case series. "Leopard spots" was the characteristic manifestation on FFA. IS/OS
loss was the most common finding in patients with posterior uveitis on SD-OCT.
Lumbar puncture can contribute to the diagnosis of neurosyphilis. Treatment for
ocular syphilis was effective in these patients.
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