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2017 ; 11
(3
): 323-334
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Obesity-Related Digestive Diseases and Their Pathophysiology
#MMPMID27890867
Nam SY
Gut Liver
2017[May]; 11
(3
): 323-334
PMID27890867
show ga
Obesity is a growing medical and public health problem worldwide. Many digestive
diseases are related to obesity. In this article, the current state of our
knowledge of obesity-related digestive diseases, their pathogenesis, and the
medical and metabolic consequences of weight reduction are discussed.
Obesity-related digestive diseases include gastroesophageal reflux disease,
Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic
fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma,
gallstone, cholangiocarcinoma, and pancreatic cancer. Although obesity-related
esophageal diseases are associated with altered mechanical and humoral factors,
other obesity-related digestive diseases seem to be associated with
obesity-induced altered circulating levels of adipocytokines and insulin
resistance. The relationship between functional gastrointestinal disease and
obesity has been debated. This review provides a comprehensive evaluation of the
obesity-related digestive diseases, including pathophysiology, obesity-related
risk, and medical and metabolic effects of weight reduction in obese subjects.
|Adipokines/blood
[MESH]
|Digestive System Diseases/etiology/*physiopathology
[MESH]