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Hum Vaccin Immunother
2014[]; 10
(4
): 887-95
PMID24365968
show ga
Obesity is one of the largest and fastest growing public health problems in the
world. Last century social changes have set an obesogenic milieu that calls for
micro and macro environment interventions for disease prevention, while treatment
is mandatory for individuals already obese. The cornerstone of overweight and
obesity treatment is diet and physical exercise. However, many patients find
lifestyle modifications difficult to comply and prone to failure in the
long-term; therefore many patients consider anti-obesity drugs an important
adjuvant if not a better alternative to behavioral approach or obesity surgery.
Since the pharmacological options for obesity treatment remain quite limited,
this is an exciting research area, with new treatment targets and strategies on
the horizon. This review discusses the development of innovative therapeutic
agents, focusing in energy homeostasis regulation and the use of molecular
vaccines, targeting hormones such as somatostatin, GIP and ghrelin, to reduce
body weight.
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