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2020 ; 14
(4
): 295-300
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Obesity and mortality of COVID-19 Meta-analysis
#MMPMID32660813
Hussain A
; Mahawar K
; Xia Z
; Yang W
; El-Hasani S
Obes Res Clin Pract
2020[Jul]; 14
(4
): 295-300
PMID32660813
show ga
BACKGROUND: Obesity is a global disease with at least 2.8 million people dying
each year as a result of being overweight or obese according to the world health
organization figures. This paper aims to explore the links between obesity and
mortality in COVID-19. METHODS: Electronic search was made for the papers
studying obesity as a risk factor for mortality following COVID-19 infection.
Three authors independently selected the papers and agreed for final inclusion.
The outcomes were the age, gender, body mass index, severe comorbidities,
respiratory support and the critical illness related mortality in COVID-19. 572
publications were identified and 42 studies were selected including one
unpublished study data. Only 14 studies were selected for quantitative analysis.
RESULTS: All the primary points but the gender are significantly associated with
COVID-19 mortality. The age >70, [odd ratio (OR): 0.17, CI; 95%, P-value:
<0.00001], gender [OR: 0.89; CI: 95%, P-value: 0.32], BMI > 25 kg/m(2) [OR: 3.68,
CI: 95%, P-value: <0.003], severe comorbidities [OR: 1.84, CI:95%, P-value:
<0.00001], advanced respiratory support [OR: 6.98, CI: 95%, P-value: <0.00001],
and critical illness [OR: 2.03, CI: 95%, P-value: <0.00001]. CONCLUSIONS:
Patients with obesity are at high risk of mortality from COVID-19 infection.
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