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2018 ; 8
(8
): 2242-2244
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OVOL2 in metastasis prevention in NPC
#MMPMID29721076
Song KA
; Faber AC
Theranostics
2018[]; 8
(8
): 2242-2244
PMID29721076
show ga
Metastasis remains a critical - and largely elusive - target in the race to
prevent cancer-related deaths. Such is true in nasopharyngeal carcinoma (NPC),
where the presentation or development of metastatic disease is usually fatal. In
this edition of Theranostics, Qi et al. demonstrate a critical role of the
zinc-finger transcription factor, OVOL2, in suppressing metastasis and
maintaining an epithelial phenotype. These data add to the depth of understanding
of the metastatic program in NPC, and may eventually lead to a druggable target
in late-stage NPC.