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10.1038/s41598-017-16750-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-16750-2 C5703718!5703718 !29180746     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29180746 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29180746 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 16357 Nephropedia Template TP {{tp|p=29180746 |t=2017. NumtS colonization in mammalian genomes |pdf=|usr=}}{{29180746 }} gab.com Text NumtS colonization in mammalian genomes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29180746 #FOAvip The colonization of the nuclear genome by mitochondrial DNA is an ongoing process in eukaryotes and plays an important role in genomic variability. Notwithstanding the DNA sequence availability of about 100 complete eukaryotic genomes, up to now NumtS distribution has been fully reported for a small number of sequenced eukaryotic species. With the aim to clarify the time and way of NumtS evolution, we explored the genomic distribution of NumtS in 23 eukaryotic species using an intra/interspecies in silico approach based on a cross-species similarity search and deeply investigate the evolution of NumtS in mammals. The intra- and interspecies analysis underlined how some mitochondrial regions that populated nuclear genomes can be considered as hotspots. Considering the large amount of NumtS we found in platypus and opossum genomes, we hypothesized the occurrence of an earlier colonization that happened prior to the Prototherian/Therian mammal divergence, approximately 160-210 million years ago. These events are still detectable due to the species-specific dynamics that have affected these genomes. Phylogenetic analyses of NumtS derived from two different mitochondrial DNA loci allowed us to recognize the unusual NumtS evolution that acted differently on primate and non-primate species' genomes. Twit Text FOAVip NumtS colonization in mammalian genomes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29180746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29180746 #FOAvip English Wikipedia <ref>{{Cite pmid|29180746 }}</ref> NumtS colonization in mammalian genomes #MMPMID29180746 Calabrese FM ; Balacco DL ; Preste R ; Diroma MA ; Forino R ; Ventura M ; Attimonelli M Sci Rep 2017[Nov]; 7 (1 ): 16357 PMID29180746 show ga The colonization of the nuclear genome by mitochondrial DNA is an ongoing process in eukaryotes and plays an important role in genomic variability. Notwithstanding the DNA sequence availability of about 100 complete eukaryotic genomes, up to now NumtS distribution has been fully reported for a small number of sequenced eukaryotic species. With the aim to clarify the time and way of NumtS evolution, we explored the genomic distribution of NumtS in 23 eukaryotic species using an intra/interspecies in silico approach based on a cross-species similarity search and deeply investigate the evolution of NumtS in mammals. The intra- and interspecies analysis underlined how some mitochondrial regions that populated nuclear genomes can be considered as hotspots. Considering the large amount of NumtS we found in platypus and opossum genomes, we hypothesized the occurrence of an earlier colonization that happened prior to the Prototherian/Therian mammal divergence, approximately 160-210 million years ago. These events are still detectable due to the species-specific dynamics that have affected these genomes. Phylogenetic analyses of NumtS derived from two different mitochondrial DNA loci allowed us to recognize the unusual NumtS evolution that acted differently on primate and non-primate species' genomes. |*DNA, Mitochondrial [MESH] |*Genome [MESH] |Animals [MESH] |Computational Biology/methods [MESH] |Databases, Genetic [MESH] |Evolution, Molecular [MESH] |Genomics/methods [MESH] |Humans [MESH] |Mammals/*genetics [MESH] |Mutagenesis, Insertional [MESH] |Phylogeny [MESH]NumtS colonization in mammalian genomes (epmc).pdf DeepDyve Pubget Overpricing