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2010 ; 1
(9
): 820-9
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Nucleosome assembly and epigenetic inheritance
#MMPMID21203924
Xu M
; Zhu B
Protein Cell
2010[Sep]; 1
(9
): 820-9
PMID21203924
show ga
In eukaryotic cells, histones are packaged into octameric core particles with DNA
wrapping around to form nucleosomes, which are the basic units of chromatin
(Kornberg and Thomas, 1974). Multicellular organisms utilise chromatin marks to
translate one single genome into hundreds of epigenomes for their corresponding
cell types. Inheritance of epigenetic status is critical for the maintenance of
gene expression profile during mitotic cell divisions (Allis et al., 2006).
During S phase, canonical histones are deposited onto DNA in a
replication-coupled manner (Allis et al., 2006). To understand how dividing cells
overcome the dilution of epigenetic marks after chromatin duplication, DNA
replication coupled (RC) nucleosome assembly has been of great interest. In this
review, we focus on the potential influence of RC nucleosome assembly processes
on the maintenance of epigenetic status.
|*Epigenesis, Genetic
[MESH]
|Animals
[MESH]
|Chromatin Assembly and Disassembly/genetics/physiology
[MESH]